BARRINGTON, Illinois (November 12, 2013) -- The National Rosacea Society (NRS) announced it has awarded funding for two new studies, in addition to continuing support for five ongoing studies during the year, as part of its research grants program to increase knowledge and understanding of the potential causes and other key aspects of rosacea.
"We are pleased to provide support for these important new studies, which build upon earlier findings that have added significantly to our knowledge about the causes of rosacea,” said Dr. Mark Dahl, chairman of the NRS Medical Advisory Board, which selects grant applications for funding. "Thanks to the donations of thousands of individuals with rosacea, ongoing research is now producing a significantly better understanding of the disease process and potential new advances in therapy."
Dr. Anna Di Nardo, associate professor of medicine at the University of California-San Diego, and colleagues were awarded $25,000 to study whether blocking the activity of mast cells in individuals with rosacea may alleviate inflammation. In an NRS-funded study completed earlier this year, Dr. Di Nardo’s group discovered that mast cells, located at the interface between the nervous system and the vascular system, are the “missing link” between rosacea triggers and inflammation. Strategically positioned just below the skin’s outer layer, mast cells have numerous receptors that can trigger a wide spectrum of cellular responses, including rosacea symptoms.The researchers further noted that in mice treated with mast cell stabilizers, inflammation did not develop.
In the new study, their goals are twofold. They will determine whether use of the mast cell stabilizer known as topical cromolyn sodium will decrease symptoms associated with rosacea. In addition, they will study whether levels of two enzymes, tryptase and chymotryptase — typically higher in rosacea patients — revert to normal after application of the mast cell stabilizer, and which of the enzymes is more important in this process.
Dr. Yoshikazu Uchida, research dermatologist, and Dr. Peter Elias, professor of dermatology at the University of California-San Francisco, were awarded $25,000 for further study of a biochemical pathway that may lead to inflammation.
In recently completed NRS-funded research, Dr. Uchida identified that such triggers as sunlight and irritated skin may stress the endoplasmic reticulum, a membrane involved in sorting proteins. In individuals with rosacea, this stress may set off a chain of chemical responses that produce symptoms of the disorder.
In the new research, the investigators will observe the effects of blocking this and other pathways. In addition, the researchers will study whether the application of topical substances known as resveratrol and fatty acid derivative blocks inflammation on skin with rosacea.
The NRS is also continuing to fund ongoing studies by Drs. Meg Gerstenblith and Daniel Popkin at Case Western Reserve University on the incidence of rosacea in fraternal and identical twins; Drs. Ulf Meyer-Hoffert and Thomas Schwartz at the University Clinic Schleswig-Holstein on inhibitors of enzymes that might contribute to the disease process; and Dr. Barbara Summerer at Johns Hopkins University School of Medicine on evaluating specific microbes in rosacea patients.
Researchers interested in applying for grants may obtain forms and instructions through the research grants section of the NRS website or by contacting the National Rosacea Society, 196 James Street, Barrington, Illinois 60010, telephone 1-888-662-5874, email firstname.lastname@example.org. The deadline for submitting proposals to receive a research grant in 2014 is May 7, 2014.
Because the cause of rosacea is unknown, a high priority in awarding grants is given to studies relating to its pathogenesis, progression, mechanism of action, cell biology and potential genetic factors. Proposals relating to epidemiology, predisposition, quality of life and relationships with environmental and lifestyle factors may also be considered.
Members of the NRS medical advisory board include Dr. Mark Dahl, professor emeritus of dermatology at Mayo Clinic-Scottsdale and former American Academy of Dermatology (AAD) president; Dr. Lynn Drake, Harvard Medical School and former AAD president; Dr. Richard Gallo, chief, division of dermatology, University of California-San Diego; Dr. Richard Granstein, chairman of dermatology, Cornell University; Dr. Julie Harper, clinical associate professor of dermatology, University of Alabama-Birmingham; Dr. Alexa Boer Kimball, director, Clinical Unit for Research Trials in Skin, Harvard Medical School; Dr. Mark Mannis, chairman of ophthalmology, University of California-Davis; Dr. David Norris, chairman of dermatology, University of Colorado and former president of the Society for Investigative Dermatology; Dr. Frank Powell, director, University College of Dublin Charles Institute, and former president of the European Academy of Dermatology and Venereology; and Dr. Martin Steinhoff, professor of dermatology, University of California-San Francisco.
About the National Rosacea Society
The National Rosacea Society is the world's largest organization dedicated to improving the lives of the many millions of Americans who suffer from this widespread but poorly understood disorder. Its mission is to raise awareness of rosacea, provide public health information on the disorder and support medical research that may lead to improvements in its management, prevention and potential cure. Comprehensive information and materials on rosacea are available on the NRS website at rosacea.org. Follow the National Rosacea Society on Facebook, Twitter or Pinterest for up-to-date information and tips on rosacea. Information may also be obtained by writing the National Rosacea Society, 196 James Street, Barrington, Illinois 60010; via email at email@example.com; or by calling its toll-free number at 1-888-NO-BLUSH.