Rosacea is a highly inflammatory skin condition driven by a complex interplay of vascular, neural, and immune mechanisms. And it is chronic, recurrent, painful, and progressively disfiguring. Because rosacea primarily affects the face, substantial emotional and psychosocial burdens accompany the increasingly oppressive physical symptoms. An individual patient’s specific profile of symptoms depends on their rosacea subtype or combination of subtypes. But every profile includes the basics—prominent redness (erythema), acne-like papules (hard lumps) and pustules (hard pus-containing lumps), highly visible enlarged blood vessel clusters, pronounced dryness, and unpleasant sensations (pain, stinging, burning, and tingling). Over 16 million people in the U.S. have been diagnosed with rosacea.¹

A disruptive characteristic of all rosacea skin causes double trouble, not only adding to the burdens of daily life, but also creating a formidable barrier to developing successful treatments. This is rosacea’s uniquely overreactive facial skin, which makes patients extremely vulnerable to flushing/blushing/dryness and/or a number of neurosensory issues from a spectrum of sources: environmental, internal, dietary, and topical—and that includes rosacea treatments themselves. Common adverse reactions to these treatments are pain, erythema, itching, and swelling. And it is considered a step forward when a topical treatment produces only mild to moderate side effects. More than 82% of patients feel that their rosacea is uncontrolled,² and less than half are satisfied with their current prescription treatments.3 A recent survey points to the need for novel topical therapies with increased efficacy and tolerability.³

Crescel Skin Renewal Cream approaches healing from a perspective that opens new doors. The revolutionary microemulsion of this novel, botanically-based anti-inflammatory and moisturizing skin cream enables it to be metabolized by skin cells, support the repair mechanism, and generate the restoration of healthy cell function. Thus this groundbreaking topical therapeutic was engineered to heal all skin conditions by enabling dysfunctional skin cells to regain their ability to heal themselves, and do so without negative side effects.

Crescel recently received the National Rosacea Society’s Seal of Acceptance, which was based on a 4-week tolerance study that documented the complete absence of worsening of any of the rosacea symptoms that are typically exacerbated by products—treatments included—that touch patients’ skin. This was a celebrated occurrence for a rosacea treatment. Patients also reported some initial symptom improvement during this brief study (less erythema, dryness, flushing frequency and severity, and papules/pustules), in line with previous studies showing clinical gains.

This boundary-breaking tolerance study was followed by another one. This time it was a 12-week efficacy trial. A randomized, controlled, blinded study was carried out by a leading independent trialist dermatologist and rosacea specialist, and aimed at a better understanding of Crescel’s beneficial effect on rosacea. The efficacy of this novel facial moisturizer on erythema and papules/pustules was assessed in patients with mild, moderate, and severe rosacea and compared to the standard-of-care—metronidazole gel (MetroCream)—used with a nonmedicated facial moisturizer (CeraVe Daily Moisturizing Lotion). Crescel’s superior efficacy was already apparent by Week 4, the very first of the assessment periods. By that early point, Crescel had already achieved a 50% greater reduction in erythema (36% vs 23%), and was 200% more effective in reducing facial lesions (52% reduction vs 17%). By Week 8, Crescel was even more strongly outperforming MetroCream with regard to both erythema and lesion reduction. And by Week 12, Crescel’s superior benefits were still more dramatic: 54% vs 23% for erythema reduction, and 74% vs a statistically nonsignificant 17% for reduction of papules/pustules. This substantially increased degree and range of therapeutic benefits, coupled with the complete absence of intolerance, point to Crescel Skin Renewal Cream’s consideration as an important first-line therapeutic for those suffering from rosacea.

Application

Crescel is applied twice daily (morning and evening) to skin that has been cleaned and allowed to dry. Gently rub the cream into the skin. Then wait at least 10 minutes before applying any skin care or cosmetic products.

References

1. Huynh TT. Burden of disease: the psychosocial impact of rosacea on a patient’s quality of life. Am Health Drug Benefits. 2013;6:348-354.

2. Rosacea: Beyond the visible report. Available at: https://www.oracea.com/sites/default/files/2021-12/rosacea-beyond-the-visible-report.pdf-min_0.pdf

3. Williamson T, Cheng WY, McCormick N, Vekeman F. Patient preferences and therapeutic satisfaction with topical agents for rosacea: A survey-based study. Am Health Drug Benefits. 2018;11:97-105.